今、世界が注目する医学論文は?
<p><span style="font-family:'Noto Sans', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, 'Helvetica Neue', Arial, 'Noto Sans', sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol', 'Noto Color Emoji';">インパクトファクターの高いジャーナルから、世界の研究者が注目する主に疾患に関する論文をご紹介します。</span></p>
今回は、①成人の注意欠如・多動症(ADHD)患者におけるビデオ会議ベースの認知行動療法(vCBT)の有効性を標準治療(TAU)と比較した結果a)、②体験学習理論(ELT)に基づき、ゲームベースのデジタル介入が小児・青年期のADHD患者の特定の認知機能および行動機能に及ぼす効果を評価した結果b)、➂反抗挑戦性障害(ODD)を併発している場合および併発していない場合の両者を含む、小児ADHD患者の保護者に対し、モバイル端末を用いた自己主導型デジタル親管理トレーニング(d-PMT)の有効性を評価した結果c)、に関する以下の報告が注目を集めた。
(検索期間:2025年6月9日~2025年7月20日まで)
-2026.2.13
今回は、①原発性硬化性胆管炎(PSC)患者と炎症性腸疾患(IBD)患者(PSCを伴わない)における免疫活性化パターンを比較した結果a)、②クローン病(CD)に関連する狭窄の診断に使用される画像パラメータを特定し、診断性能を評価し、研究間の一貫性を評価した結果b)、➂潰瘍性大腸炎(UC)患者における経口凍結乾燥便微生物叢移植(FMT)の及ぼすドナー由来種の定着状況および本療法の有効性に関わる要因を評価した結果c)、に関する以下の報告が注目を集めた。
(検索期間:2025年10月4日~10月22日まで)
-2026.2.13
今回は、①クローン病(CD)における、浸潤性脂肪(CF)の腸管腔狭窄に与える影響を評価した結果a)、②潰瘍性大腸炎(UC)における、臨床的・内視鏡的寛解(CER)および組織学的・内視鏡的粘膜改善(HEMI)に関する腸管超音波検査(IUS)による早期予測の可否を評価した結果b)、③炎症性腸疾患(IBD)患者における肺病変の有病率、臨床症状、および臨床的意義を評価した結果c)、に関する以下の報告が注目を集めた。
(検索期間:2025年9月16日~10月3日まで)
-2026.2.12
2025.11.30 ADHD
a) Acceptance and Commitment Therapy-Based Parenting Program in Children with Co-Occurring Asthma and ADHD: A Randomized Clinical Trial
b) Sensory Processing in Individuals With Attention-Deficit/Hyperactivity Disorder Compared With Control Populations: A Systematic Review and Meta-analysis
c) Effectiveness of a cognitive-behavioral sleep hygiene intervention for adolescents with ADHD: a randomized controlled trial
2025.11.30 IBD
a) The predictive role of peripheral serum inflammatory markers NLR, PLR, and LMR in ulcerative colitis and Crohn’s disease: a systematic review and meta-analysis
b) Non-Invasive vs. Invasive Markers in Ulcerative colitis: A Systematic Review of Intestinal Ultrasound, Biopsy, and Faecal Calprotectin
c) Gut microbiome-targeted therapies as adjuvant treatments in Inflammatory Bowel Diseases: a systematic review and network meta-analysis
2025.11.30 IBD
a) Patient-Reported Outcome Measures Poorly Correlate with Objective Inflammatory Bowel Disease Activity Measures: A Systematic Review
b) Acceptance and Commitment Therapy for Adults Living With Inflammatory Bowel Disease and Distress: A Randomized Controlled Trial
c) Hemophagocytic lymphohistiocytosis in patients with Inflammatory Bowel Diseases: a systematic review
2025.10.31 ADHD
a) Efficacy of guided and unguided web-assisted self-help for parents of children with attention-deficit/hyperactivity disorder and oppositional defiant disorder: A three-arm randomized controlled trial
b) Psychiatric comorbidity in children and adolescents with ADHD: A systematic review and meta-analysis
c) Sensory Processing in Individuals With Attention-Deficit/Hyperactivity Disorder Compared to Control Populations: A Systematic Review and Meta-Analysis
2025.10.31 IBD
a) A Pilot Randomized Control Trial to Assess the Adjunctive Effect of Diet on Response to Advanced Therapies in Patients With Ulcerative colitis
b) Inflammatory Bowel Diseases-Specific Cognitive Behavioral Therapy Delivered via Telehealth RedUCes Disability: ADEPT (Addressing Disability Effectively with Psychosocial Telemedicine) Pragmatic Randomized Controlled Trial
c) Results of the 9th Scientific Workshop of the European Crohn's and Colitis Organisation (ECCO): Artificial Intelligence in medical management and precision medicine
2025.10.31 IBD
a) A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn’s disease (PROFILE): a multicentre, open-label randomised controlled trial
b) Scoring indices for assessing endoscopic disease activity in acute severe ulcerative colitis: A systematic review
c) Endo-Histo foundational fusion model: a novel artificial intelligence for assessing histologic remission and response to therapy in ulcerative colitis clinical trial
2025.9.30 ADHD
a) Gut microbiome changes with micronutrient supplementation in children with attention–deficit/hyperactivity disorder: the MADDY study
b) Prefrontal Transcranial Direct Current Stimulation in Pediatric Attention–deficit/hyperactivity disorder: A Randomized Clinical Trial
c) Attention–deficit/hyperactivity disorder and post-traumatic stress disorder adult comorbidity: a systematic review
2025.9.30 IBD
a) Preliminary Results from a Multicenter, Randomized Trial Using Fecal Microbiota Transplantation to Induce Remission in Patients with Mild-to-Moderate Crohn’s Disease
b) Whole food diet induces remission in children and young adults with mild-moderate Crohn’s disease and is more tolerable than exclusive enteral nutrition: a randomized controlled trial
c) Impact of diet on Inflammatory Bowel Disease risk: systematic review, meta-analyses and implications for prevention
2025.9.30 IBD
a) Diagnostic Accuracy of Non-Invasive Biomarkers and Imaging for Evaluating Postoperative Recurrence in Crohn’s Disease
b) Gene-Environment Interactions in Inflammatory Bowel Disease: A Systematic Review of Human Epidemiologic Studies
c) ECCO Topical Review on Predictive Models on Inflammatory Bowel Disease Disease Course and Treatment Response
2025.8.29 ADHD
a) Research Review: Mechanisms of change and between-family differences in parenting interventions for children with ADHD - an individual participant data meta-analysis
b) Pilot randomised controlled trial on the feasibility and intervention satisfaction with an educational group programme for adults with Attention-Deficit/Hyperactivity Disorder and their caregivers
c) Digital health interventions with healthcare information and self-management resources for young people with ADHD: a mixed-methods systematic review and narrative synthesis
2025.8.29 IBD
a) Virome drift in ulcerative colitis patients: faecal microbiota transplantation results in minimal phage engraftment dominated by microviruses
b) Development of a capsule endoscopy scoring system for the early diagnosis of small bowel Crohn’s Disease
c) The Association Between Fast Food Consumption and Inflammatory Bowel Disease: A Case-Control Study and Meta-Analysis
2025.8.27 IBD
a) ECCO topical review on predictive models on IBD disease course and treatment response
b) Expert recommendations to standardize transcriptomic analysis in inflammatory bowel disease clinical trials
c) Colorectal cancer risk in ulcerative colitis: an updated population-based systematic review and meta-analysis