今、世界が注目する医学論文は？
<p><span style="font-family:'Noto Sans', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, 'Helvetica Neue', Arial, 'Noto Sans', sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol', 'Noto Color Emoji';">インパクトファクターの高いジャーナルから、世界の研究者が注目する主に疾患に関する論文をご紹介します。</span></p>
今回は、①薬物療法のランダム化比較試験(RCT)に不適格となる注意欠陥・多動性障害(ADHD)患者の割合を明らかにし、RCT適格者とRCT不適格者の治療パターンや臨床的・機能的転帰の違いを評価した結果a)、②精神病性障害におけるADHDの有病率のばらつきに影響を与える因子を評価した結果b)、③ADHDに感情処理の欠損があるかを評価した結果c)、に関する以下の報告が注目を集めた。
（検索期間：2025年1月24日～2025年2月20日まで）
-2025.7.31
今回は、①潰瘍性大腸炎(UC)患者の寛解維持における腹腔鏡下虫垂切除術の臨床的有効性を評価した結果a)、②孤立性肛門周囲クローン病(CD)の診断フレームワークの構築b)、③肛門周囲瘻孔形成性CD(pfCD)における放射線学的治癒の定義について国際的なコンセンサスの確立c)、に関する以下の報告が注目を集めた。
（検索期間：2025年4月22日～ 5月7日まで）
-2025.7.31
今回は、①クローン病(CD)における目標を明確にした治療(treat-to-target:T2T)の最適化に果たすビデオカプセル内視鏡(VCE)の価値を評価した結果a)、②診断、再発の定義、および回腸ストーマを有するCD患者の管理に関する既存のデータを評価した結果b)、に関する以下の報告が注目を集めた。
（検索期間：2025年4月2日～4月21日まで）
-2025.7.29
2025.6.30 ADHD
a) Review: Animal-assisted intervention for children with attention-deficit/hyperactivity disorder – a systematic review and meta-analysis
b) Physical and neurophysiological maturation associated with ADHD among previously institutionalized children: a randomized controlled trial
c) Comparative effectiveness of physical activity interventions on cognitive functions in children and adolescents with Neurodevelopmental Disorders: a systematic review and network meta-analysis of randomized controlled trials
2025.6.30 IBD
a) Spleen volume in relation to Ulcerative Colitis and Crohn’s Disease: a Mendelian randomization study
b) Surveillance in inflammatory bowel disease: white light endoscopy with segmental re-inspection versus dye-based chromoendoscopy – a multi-arm randomised controlled trial (HELIOS)
c) Definitions, Diagnosis and Management of Postoperative Recurrence in Crohn’s Disease Patients with Permanent Ileostomy - A Systematic Review and Meta-Analysis
2025.6.30 IBD
a) Evaluating the Efficacy of Probiotics on Disease Progression, Quality of Life, and Nutritional Status Among Patients with Crohn’s Disease: A Multicenter, Randomized, Single-Blinded Controlled Trial
b) Novel Microbial Engraftment Trajectories Following Microbiota Transplant Therapy in Ulcerative Colitis
c) Reliability and Responsiveness of Clinical and Endoscopic Outcome Measures in Crohn’s Disease
2025.5.30 ADHD
a) The efficacy of behavioral sleep intervention on sleep problems among children with attention deficit hyperactivity disorder: A randomized controlled trial
b) Impact of a physical exercise intervention on psychological resilience and mental ill-being in medical-naïve children with attention deficit hyperactivity disorder: a pilot randomized controlled trial
c) Neurofeedback for Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis
2025.5.30 IBD
a) Modified Crohn’s Disease Exclusion Diet Maintains Remission in Pediatric Crohn’s Disease: Randomized Controlled Trial
b) Risk factors for inflammatory bowel disease: an umbrella review
c) Assessment of activity and severity of inflammatory bowel disease in cross-sectional imaging techniques: a systematic review
2025.5.29 IBD
a) Assessment and Reporting of Extraintestinal Manifestations and Fatigue in Phase 3 Inflammatory Bowel Disease Clinical Trials
b) Operating Properties of Disease Activity Indices in Pediatric Inflammatory Bowel Disease: A Systematic Review
c) A meta-analysis of the gut microbiome in inflammatory bowel disease patients identifies disease-associated small molecules
2025.4.28 ADHD
a) Innovations in Practice: Brief behavioral parent training for children with impairing ADHD characteristics – a pilot study
b) Impulsivity in ADHD and Borderline Personality Disorder: A Systematic Review of Gray and White Matter Variations
c) A Systematic Review on Social Cognition in ADHD: The Role of Language, Theory of Mind, and Executive Function
2025.4.28 IBD
a) Mechanistic implications of the Mediterranean diet in patients with newly diagnosed Crohn's disease- multi-omic results from a prospective cohort
b) Systematic Review on definitions of Intestinal Ultrasound Treatment Response and Remission in Inflammatory Bowel Disease
c) Dietary Interventions and Supplementation in Patients With an Ileal Pouch–Anal Anastomosis: A Systematic Review
2025.4.25 IBD
a) Artificial intelligence–enabled histology exhibits comparable accuracy to pathologists in assessing histological remission in ulcerative colitis: a systematic review, meta-analysis, and meta-regression
b) Meta-Analysis: Exclusive Enteral Nutrition in Adults With Ulcerative Colitis
c) Network Meta-Analysis: Comparison of Endoscopic Dysplasia Detection Technologies in Inflammatory Bowel Disease
2025.3.31 ADHD
a) Systematic Review: Assessment of Blinding Integrity in 161 Randomized Controlled Trials of Medications for Attention deficit / hyperactivity disorder
b) A systematic review and meta-analysis comparing the severity of core symptoms of attention deficit hyperactivity disorder in females and males
c) Exploring the impact of probiotics on adult ADHD management through a double-blind RCT
2025.3.31 IBD
a) Acute Severe Ulcerative colitis: An International Delphi Consensus on Clinical Trial Design and Endpoints
b) Modifiable psychological factors are associated with clusters of pain, fatigue, faecal incontinence and IBS-type symptoms in inflammatory bowel disease: a latent profile analysis
c) Rigorous Donor Selection for Fecal Microbiota Transplantation in Active Ulcerative Colitis: Key Lessons From a Randomized Controlled Trial Halted for Futility
2025.3.31 IBD
a) Nutritional Management in Stricturing Crohn’s disease: A Pilot Study
b) Efficacy and Safety of Anthocyanin-Rich Extract in Patients with Ulcerative colitis: A Randomized Controlled Trial
c) Multi-Omics Biomarkers for Predicting Efficacy of Biologic and Small-Molecule Therapies in Adults With Inflammatory bowel disease: A Systematic Review
2025.2.28 IBD
a) Partial Enteral Nutrition in the Management of Crohn’s Disease: A Systematic Review and Meta-Analysis
b) Preliminary results from a multicenter, randomized trial using fecal microbial transplantation to induce remission in patients with mild to moderate Crohn’s Disease
c) Telemonitoring of Active Inflammatory bowel disease Using the App TECCU: Short-Term Results of a Multicenter Trial of GETECCU
2025.2.27 IBD
a) Repeated endoscopic dilation and needle-knife stricturotomy for Crohn's disease strictures
b) A Core Outcome Set for Inflammatory Bowel Diseases: Development and Recommendations for Implementation in Clinical PracticeThrough an International Multistakeholder Consensus Process
c) Vascular endothelial growth factor in inflammatory bowel disease: A systematic review and meta-analysis
2025.1.31 IBD
a) Eosinophils and risk of ulcerative colitis in European population: Evidence from Mendelian randomization study
b) Therapeutic and Immunologic Effects of Short-Chain Fatty Acids in Inflammatory Bowel Disease: A Systematic Review
c) Mendelian randomization reveals predictive, preventive, and personalized insights into inflammatory bowel disease: the role of gut microbiome and circulating inflammatory proteins
2025.1.31 IBD
a) The association between bilirubin concentrations and inflammatory bowel disease: Insights from a systematic review and meta-analysis
b) Meta-analysis: Risk of lymphoma in patients with inflammatory bowel disease in population-based cohort studies
c) Gut Microbiota Features in Relation to Fecal Microbiota Transplantation Outcome in Ulcerative Colitis: A Systematic Review and Meta-Analysis
2024.12.24 IBD
a) Harms with placebo in trials of biological therapies and small molecules as induction therapy in inflammatory bowel disease: a systematic review and meta-analysis
b) Harms with placebo in trials of biological therapies and small molecules as maintenance therapy in inflammatory bowel disease: a systematic review and meta-analysis
c) Rates of Endoscopic Recurrence In Postoperative Crohn's Disease Based on Anastomotic Techniques: A Systematic Review And Meta-Analysis
2024.12.09 IBD
a) Comparing the Diagnostic Value of FDG PET or PET/CT with FDG PET/MR in Inflammatory Bowel Disease-A Systematic Review and Meta-analysis
b) The impact of group cognitive behavioral psychotherapy on disease severity and psychosocial functioning in patients with inflammatory bowel disease: a randomized controlled study
c) Oxidative stress-related biomarkers as promising indicators of inflammatory bowel disease activity: A systematic review and meta-analysis
2024.11.27 IBD
a) Chronic Kidney Disease in Inflammatory bowel disease: a Systematic Review and Meta-analysis
b) Prevalence of Sexual Dysfunction In Inflammatory bowel disease: Systematic Review and Meta-Analysis
c) Emerging role of environmental pollutants in Inflammatory bowel disease risk, outcomes and underlying mechanisms
2024.11.12 IBD
a) A global consensus on the definitions, diagnosis and management of fibrostenosing small bowel Crohn’s disease in clinical practice
b) Whole blood DNA methylation changes are associated with anti-TNF drug concentration in patients with Crohn's disease
c) Efficacy and safety of probiotics in IBD: An overview of systematic reviews and updated meta-analysis of randomized controlled trials
2024.10.21 IBD
a) Effect of mesenteric sparing or extended resection in primary ileocolic resection for Crohn's disease on postoperative endoscopic recurrence (SPICY): an international, randomised controlled trial
b) Systematic review: Patient-related, microbial, surgical, and histopathological risk factors for endoscopic post-operative recurrence in patients with Crohn's disease
c) Effect of hydrogel drug delivery system for treating ulcerative colitis: A preclinical meta-analysis
2024.10.04 IBD
a) Fungal Microbiota Composition in Inflammatory Bowel Disease Patients: Characterization in Different Phenotypes and Correlation With Clinical Activity and Disease Course
b) Single-Cell Transcriptomic and Targeted Genomic Profiling Adjusted for Inflammation and Therapy Bias Reveal CRTAM and PLCB1 as Novel Hub Genes for Anti-Tumor Necrosis Factor Alpha Therapy Response in Crohn’s Disease
c) Early Biologic Treatment Decreases Risk of Surgery in Crohn’s Disease but not in Ulcerative Colitis: Systematic Review and Meta-Analysis