今、世界が注目する医学論文は？
<p><span style="font-family:'Noto Sans', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, 'Helvetica Neue', Arial, 'Noto Sans', sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol', 'Noto Color Emoji';">インパクトファクターの高いジャーナルから、世界の研究者が注目する主に疾患に関する論文をご紹介します。</span></p>
今回は、①注意欠陥・多動性障害(ADHD)における、短期間の行動理論を基盤としたペアレント・トレーニング(BPT)の実現可能性と効果を評価した結果a)、②境界性パーソナリティ障害(BPD)とADHDにおける衝動性に関連する神経生物学的異常を評価した結果b)、③社会的認知に関連する認知過程における、ADHD群と対照群間の差異を評価した結果c)、に関する以下の報告が注目を集めた。
（検索期間：2024年11月18日～12月15日まで）
-2025.4.28
今回は、①クローン病(CD)における地中海式ダイエット(MED)の保護的作用の機序を評価した結果a)、②炎症性腸疾患(IBD)における腸管超音波検査(IUS)の有効性を評価した結果b)、③回腸嚢-肛門吻合術を受けた患者の回腸嚢の機能および回腸嚢炎に対する食事療法の効果を評価した結果c)、に関する以下の報告が注目を集めた。
（検索期間：2025年1月24日～ 2月6日まで）
-2025.4.28
今回は、①潰瘍性大腸炎(UC)における組織学的寛解の評価に人工知能(AI)が利用できる可能性を評価した結果a)、②活動性UC成人患者における完全経腸栄養療法(EEN)の有効性を評価した結果b)、③炎症性腸疾患(IBD)に対する新しい大腸内視鏡サーベイランス技術を活用した異形成検出を評価した結果c)、に関する以下の報告が注目を集めた。
（検索期間：2025年1月11日～1月23日まで）
-2025.4.25
2025.3.31 ADHD
a) Systematic Review: Assessment of Blinding Integrity in 161 Randomized Controlled Trials of Medications for Attention deficit / hyperactivity disorder
b) A systematic review and meta-analysis comparing the severity of core symptoms of attention deficit hyperactivity disorder in females and males
c) Exploring the impact of probiotics on adult ADHD management through a double-blind RCT
2025.3.31 IBD
a) Acute Severe Ulcerative colitis: An International Delphi Consensus on Clinical Trial Design and Endpoints
b) Modifiable psychological factors are associated with clusters of pain, fatigue, faecal incontinence and IBS-type symptoms in inflammatory bowel disease: a latent profile analysis
c) Rigorous Donor Selection for Fecal Microbiota Transplantation in Active Ulcerative Colitis: Key Lessons From a Randomized Controlled Trial Halted for Futility
2025.3.31 IBD
a) Nutritional Management in Stricturing Crohn’s disease: A Pilot Study
b) Efficacy and Safety of Anthocyanin-Rich Extract in Patients with Ulcerative colitis: A Randomized Controlled Trial
c) Multi-Omics Biomarkers for Predicting Efficacy of Biologic and Small-Molecule Therapies in Adults With Inflammatory bowel disease: A Systematic Review
2025.2.28 IBD
a) Partial Enteral Nutrition in the Management of Crohn’s Disease: A Systematic Review and Meta-Analysis
b) Preliminary results from a multicenter, randomized trial using fecal microbial transplantation to induce remission in patients with mild to moderate Crohn’s Disease
c) Telemonitoring of Active Inflammatory bowel disease Using the App TECCU: Short-Term Results of a Multicenter Trial of GETECCU
2025.2.27 IBD
a) Repeated endoscopic dilation and needle-knife stricturotomy for Crohn's disease strictures
b) A Core Outcome Set for Inflammatory Bowel Diseases: Development and Recommendations for Implementation in Clinical PracticeThrough an International Multistakeholder Consensus Process
c) Vascular endothelial growth factor in inflammatory bowel disease: A systematic review and meta-analysis
2025.1.31 IBD
a) Eosinophils and risk of ulcerative colitis in European population: Evidence from Mendelian randomization study
b) Therapeutic and Immunologic Effects of Short-Chain Fatty Acids in Inflammatory Bowel Disease: A Systematic Review
c) Mendelian randomization reveals predictive, preventive, and personalized insights into inflammatory bowel disease: the role of gut microbiome and circulating inflammatory proteins
2025.1.31 IBD
a) The association between bilirubin concentrations and inflammatory bowel disease: Insights from a systematic review and meta-analysis
b) Meta-analysis: Risk of lymphoma in patients with inflammatory bowel disease in population-based cohort studies
c) Gut Microbiota Features in Relation to Fecal Microbiota Transplantation Outcome in Ulcerative Colitis: A Systematic Review and Meta-Analysis
2024.12.24 IBD
a) Harms with placebo in trials of biological therapies and small molecules as induction therapy in inflammatory bowel disease: a systematic review and meta-analysis
b) Harms with placebo in trials of biological therapies and small molecules as maintenance therapy in inflammatory bowel disease: a systematic review and meta-analysis
c) Rates of Endoscopic Recurrence In Postoperative Crohn's Disease Based on Anastomotic Techniques: A Systematic Review And Meta-Analysis
2024.12.09 IBD
a) Comparing the Diagnostic Value of FDG PET or PET/CT with FDG PET/MR in Inflammatory Bowel Disease-A Systematic Review and Meta-analysis
b) The impact of group cognitive behavioral psychotherapy on disease severity and psychosocial functioning in patients with inflammatory bowel disease: a randomized controlled study
c) Oxidative stress-related biomarkers as promising indicators of inflammatory bowel disease activity: A systematic review and meta-analysis
2024.11.27 IBD
a) Chronic Kidney Disease in Inflammatory bowel disease: a Systematic Review and Meta-analysis
b) Prevalence of Sexual Dysfunction In Inflammatory bowel disease: Systematic Review and Meta-Analysis
c) Emerging role of environmental pollutants in Inflammatory bowel disease risk, outcomes and underlying mechanisms
2024.11.12 IBD
a) A global consensus on the definitions, diagnosis and management of fibrostenosing small bowel Crohn’s disease in clinical practice
b) Whole blood DNA methylation changes are associated with anti-TNF drug concentration in patients with Crohn's disease
c) Efficacy and safety of probiotics in IBD: An overview of systematic reviews and updated meta-analysis of randomized controlled trials
2024.10.21 IBD
a) Effect of mesenteric sparing or extended resection in primary ileocolic resection for Crohn's disease on postoperative endoscopic recurrence (SPICY): an international, randomised controlled trial
b) Systematic review: Patient-related, microbial, surgical, and histopathological risk factors for endoscopic post-operative recurrence in patients with Crohn's disease
c) Effect of hydrogel drug delivery system for treating ulcerative colitis: A preclinical meta-analysis
2024.10.04 IBD
a) Fungal Microbiota Composition in Inflammatory Bowel Disease Patients: Characterization in Different Phenotypes and Correlation With Clinical Activity and Disease Course
b) Single-Cell Transcriptomic and Targeted Genomic Profiling Adjusted for Inflammation and Therapy Bias Reveal CRTAM and PLCB1 as Novel Hub Genes for Anti-Tumor Necrosis Factor Alpha Therapy Response in Crohn’s Disease
c) Early Biologic Treatment Decreases Risk of Surgery in Crohn’s Disease but not in Ulcerative Colitis: Systematic Review and Meta-Analysis