今、世界が注目する医学論文は？
<p><span style="font-family:'Noto Sans', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, 'Helvetica Neue', Arial, 'Noto Sans', sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol', 'Noto Color Emoji';">インパクトファクターの高いジャーナルから、世界の研究者が注目する主に疾患に関する論文をご紹介します。</span></p>
今回は、①注意欠陥・多動性障害(ADHD)と診断された小児の睡眠問題の緩和、生活の質(QoL)の向上、ADHD症状の重症度の軽減に対する睡眠介入の有効性を評価した結果a)、②未治療の小児ADHD患者における身体運動介入の心理的レジリエンスと精神的不調に対する有効性を評価した結果b)、③ADHD治療におけるニューロフィードバックの有効性を、中核症状の軽減と神経心理学的転帰の改善という観点から検証した結果c)、に関する以下の報告が注目を集めた。
（検索期間：2024年12月16日～2025年1月1日まで）
-2025.5.30
今回は、①軽症から重症のクローン病(CD)において、完全経腸栄養(EEN)投与とCD除外食(CDED)および部分経腸栄養(PEN)の併用(CDED+PEN)投与の有効性の比較、およびCDED+PEN投与による寛解の維持を評価した結果a)、②炎症性腸疾患(IBD)発症のリスク因子に関するエビデンスを包括的に評価した結果b)、③IBD患者におけるCross-sectional imaging法(CSI)による疾患活動性、重症度の評価および活用法に関するガイダンスc)、に関する以下の報告が注目を集めた。
（検索期間：2025年2月19日～ 3月4日まで）
-2025.5.30
今回は、①炎症性腸疾患(IBD)を対象としたRCTにおける腸管外合併症(EIMs)および疲労の報告パターンを評価した結果a)、②小児IBD(pIBD)のランダム化比較試験(RCT)で使用されたすべてのスコアリング指標を同定し、その実用性を評価した結果b)、③IBDに対する腸内細菌叢由来の小分子の影響を評価した結果c)、に関する以下の報告が注目を集めた。
（検索期間：2025年2月7日～2月18日まで）
-2025.5.29
2025.4.28 ADHD
a) Innovations in Practice: Brief behavioral parent training for children with impairing ADHD characteristics – a pilot study
b) Impulsivity in ADHD and Borderline Personality Disorder: A Systematic Review of Gray and White Matter Variations
c) A Systematic Review on Social Cognition in ADHD: The Role of Language, Theory of Mind, and Executive Function
2025.4.28 IBD
a) Mechanistic implications of the Mediterranean diet in patients with newly diagnosed Crohn's disease- multi-omic results from a prospective cohort
b) Systematic Review on definitions of Intestinal Ultrasound Treatment Response and Remission in Inflammatory Bowel Disease
c) Dietary Interventions and Supplementation in Patients With an Ileal Pouch–Anal Anastomosis: A Systematic Review
2025.4.25 IBD
a) Artificial intelligence–enabled histology exhibits comparable accuracy to pathologists in assessing histological remission in ulcerative colitis: a systematic review, meta-analysis, and meta-regression
b) Meta-Analysis: Exclusive Enteral Nutrition in Adults With Ulcerative Colitis
c) Network Meta-Analysis: Comparison of Endoscopic Dysplasia Detection Technologies in Inflammatory Bowel Disease
2025.3.31 ADHD
a) Systematic Review: Assessment of Blinding Integrity in 161 Randomized Controlled Trials of Medications for Attention deficit / hyperactivity disorder
b) A systematic review and meta-analysis comparing the severity of core symptoms of attention deficit hyperactivity disorder in females and males
c) Exploring the impact of probiotics on adult ADHD management through a double-blind RCT
2025.3.31 IBD
a) Acute Severe Ulcerative colitis: An International Delphi Consensus on Clinical Trial Design and Endpoints
b) Modifiable psychological factors are associated with clusters of pain, fatigue, faecal incontinence and IBS-type symptoms in inflammatory bowel disease: a latent profile analysis
c) Rigorous Donor Selection for Fecal Microbiota Transplantation in Active Ulcerative Colitis: Key Lessons From a Randomized Controlled Trial Halted for Futility
2025.3.31 IBD
a) Nutritional Management in Stricturing Crohn’s disease: A Pilot Study
b) Efficacy and Safety of Anthocyanin-Rich Extract in Patients with Ulcerative colitis: A Randomized Controlled Trial
c) Multi-Omics Biomarkers for Predicting Efficacy of Biologic and Small-Molecule Therapies in Adults With Inflammatory bowel disease: A Systematic Review
2025.2.28 IBD
a) Partial Enteral Nutrition in the Management of Crohn’s Disease: A Systematic Review and Meta-Analysis
b) Preliminary results from a multicenter, randomized trial using fecal microbial transplantation to induce remission in patients with mild to moderate Crohn’s Disease
c) Telemonitoring of Active Inflammatory bowel disease Using the App TECCU: Short-Term Results of a Multicenter Trial of GETECCU
2025.2.27 IBD
a) Repeated endoscopic dilation and needle-knife stricturotomy for Crohn's disease strictures
b) A Core Outcome Set for Inflammatory Bowel Diseases: Development and Recommendations for Implementation in Clinical PracticeThrough an International Multistakeholder Consensus Process
c) Vascular endothelial growth factor in inflammatory bowel disease: A systematic review and meta-analysis
2025.1.31 IBD
a) Eosinophils and risk of ulcerative colitis in European population: Evidence from Mendelian randomization study
b) Therapeutic and Immunologic Effects of Short-Chain Fatty Acids in Inflammatory Bowel Disease: A Systematic Review
c) Mendelian randomization reveals predictive, preventive, and personalized insights into inflammatory bowel disease: the role of gut microbiome and circulating inflammatory proteins
2025.1.31 IBD
a) The association between bilirubin concentrations and inflammatory bowel disease: Insights from a systematic review and meta-analysis
b) Meta-analysis: Risk of lymphoma in patients with inflammatory bowel disease in population-based cohort studies
c) Gut Microbiota Features in Relation to Fecal Microbiota Transplantation Outcome in Ulcerative Colitis: A Systematic Review and Meta-Analysis
2024.12.24 IBD
a) Harms with placebo in trials of biological therapies and small molecules as induction therapy in inflammatory bowel disease: a systematic review and meta-analysis
b) Harms with placebo in trials of biological therapies and small molecules as maintenance therapy in inflammatory bowel disease: a systematic review and meta-analysis
c) Rates of Endoscopic Recurrence In Postoperative Crohn's Disease Based on Anastomotic Techniques: A Systematic Review And Meta-Analysis
2024.12.09 IBD
a) Comparing the Diagnostic Value of FDG PET or PET/CT with FDG PET/MR in Inflammatory Bowel Disease-A Systematic Review and Meta-analysis
b) The impact of group cognitive behavioral psychotherapy on disease severity and psychosocial functioning in patients with inflammatory bowel disease: a randomized controlled study
c) Oxidative stress-related biomarkers as promising indicators of inflammatory bowel disease activity: A systematic review and meta-analysis
2024.11.27 IBD
a) Chronic Kidney Disease in Inflammatory bowel disease: a Systematic Review and Meta-analysis
b) Prevalence of Sexual Dysfunction In Inflammatory bowel disease: Systematic Review and Meta-Analysis
c) Emerging role of environmental pollutants in Inflammatory bowel disease risk, outcomes and underlying mechanisms
2024.11.12 IBD
a) A global consensus on the definitions, diagnosis and management of fibrostenosing small bowel Crohn’s disease in clinical practice
b) Whole blood DNA methylation changes are associated with anti-TNF drug concentration in patients with Crohn's disease
c) Efficacy and safety of probiotics in IBD: An overview of systematic reviews and updated meta-analysis of randomized controlled trials
2024.10.21 IBD
a) Effect of mesenteric sparing or extended resection in primary ileocolic resection for Crohn's disease on postoperative endoscopic recurrence (SPICY): an international, randomised controlled trial
b) Systematic review: Patient-related, microbial, surgical, and histopathological risk factors for endoscopic post-operative recurrence in patients with Crohn's disease
c) Effect of hydrogel drug delivery system for treating ulcerative colitis: A preclinical meta-analysis
2024.10.04 IBD
a) Fungal Microbiota Composition in Inflammatory Bowel Disease Patients: Characterization in Different Phenotypes and Correlation With Clinical Activity and Disease Course
b) Single-Cell Transcriptomic and Targeted Genomic Profiling Adjusted for Inflammation and Therapy Bias Reveal CRTAM and PLCB1 as Novel Hub Genes for Anti-Tumor Necrosis Factor Alpha Therapy Response in Crohn’s Disease
c) Early Biologic Treatment Decreases Risk of Surgery in Crohn’s Disease but not in Ulcerative Colitis: Systematic Review and Meta-Analysis